POEM 10.03.17

Patient Oriented Evidence that Matters

Q. Low dose Perindopril…whats the point?

RAS inhibitors’ dose-dependent efficacy: myth or reality?[Curr Med Res Opin. 2015]

Perindopril is the only ACE inhibitor to show a real dose-response curve for BP decrease. While the effectiveness of RAS blockers on target organ damage is dose dependent and at least partially unrelated to BP control, there is evidence that the only way to obtain a beneficial effect is to use them at full dose.

A. Go hard and recheck renal function in 8 weeks.